Exec VP:Alliances & Operations . Acerta Pharma BV is a Biotech company that combines two technology platforms in drug discovery and development: the Covalent Technology Platform and the Multiparametric Phosphoflow Cytometry Platform.

Acerta Pharma, the innovator responsible for the discovery and development of acalabrutinib, is a clinical stage biopharmaceutical company recently founded in 2012 in Oss, the Netherlands. Acerta Pharma is also conducting multiple healthy volunteer trials and planning additional combination trials in conjunction with AstraZeneca targeted inhibitors. Designation based on positive results from two Phase III trialsAcerta Pharma is a leader in the field of covalent binding technology and is applying this technology to create a range of highly selective therapies for cancer.Working together Acerta and AstraZeneca are focused on Innovative Clinical Strategies to enable us to combine our extensive oncology portfolio of cancer therapies.Our multiparametric phospho-proteomic platform enables the characterization of activated signaling networks within complex tissues and in discrete cell subsets.Our Translational Medicine (TM) team are actively implementing MRD endpoints in our clinical trials to understand what treatments can drive to MRD undetectable levels.At our recently expanded site at Oss in the Netherlands, we have core capabilities in target identification, target validation, lead generation and compound optimization.

Pharmazeuten sind Personen, die das zweite Staatsexamen des Pharmaziestudiums bestanden haben.

The Oss research centre is based in the heart of the Pivot Park Biotechnology Campus and has established relationships with both academic and commercial partners in Europe.Senior Scientist/Associate Principal Scientist, Translational Medicine Senior Scientist/Associate Principal Scientist, Translational Medicine

Acalabrutinib is a small-molecule oral drug candidate that covalently binds to BTK.

Acerta Pharma is a leader in the field of covalent binding technology and is applying this technology to create novel, highly selective therapies for cancer. AstraZeneca PLC is a British-Swedish multinational pharmaceutical and biopharmaceutical company with its global headquarters in Cambridge, England. We have created a browser extension. Learn more… After promising results for CLL in initial clinical trials, [4] Astra Zeneca purchased a 55% stake in Acerta Pharma for $4 billion in December 2015, with an option to acquire the remaining 45% stake for an additional $3 billion, conditional on approval in both the US and Europe and the establishment of commercial opportunity. Acerta Pharma B.V. werd in 2012 opgericht door Allard Kaptein en Tjeerd Barf.

AstraZeneca plans to use some of the proceeds of a $3.5 billion share issue to fund the deal.

An AstraZeneca spokesman said the funding also covers development and clinical testing.On 31 August 2020, AstraZeneca announced that it had begun enrolling adults for a U.S.-funded, 30,000-subject late-stage study of its COVID-19 vaccine candidate, AZD1222.On 8 September 2020, AstraZeneca announced a global halt to the vaccine trial, while a possible adverse reaction in a participant in the United Kingdom is investigated.The following is an illustration of the company's major mergers and acquisitions and historical predecessors:AstraZeneca develops, manufactures and sells pharmaceutical and biotechnology products to treat disorders in the AstraZeneca has its corporate headquarters in Cambridge, United Kingdom, and its main As of 2008, David Brennan was paid $1,574,144 for his role as chief executive officer.On 26 April 2012 it was announced that Brennan was to retire early in the June of that yearThe company's most commercially successful medication is The (R)-enantiomer of omeprazole is metabolized exclusively by the enzyme CYP2C19, which is expressed in very low amounts by 3% of the population.

Acerta is gevestigd op het Pivot Park in Oss en heeft ook een vestiging in San Carlos in de Verenigde Staten. The information provided here regarding acalabrutinib is for indications that are currently under investigation. Treated with a normal dose of the enantiomeric mixture, these persons will experience blood levels five-times higher than those with normal CYP2C19 production. Originating from groundbreaking research conducted at the University of Waterloo, Acerta is maximizing the value of automotive data. These platforms ensure rapid identification and optimization of high-quality drug candidates and enable administering the right drug to the right patient at the right dose. Acerta Pharma has applied its expertise in covalent technology to the selective targeting of BTK while minimizing inhibition of non-BTK kinases.

Acerta Pharma is looking for highly motivated individuals who share our values.

Every page goes through CC#CC(=O)N1CCC[C@H]1c2nc(c3n2ccnc3N)c4ccc(cc4)C(=O)Nc5ccccn5InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1✪ Acalabrutinib for Treating Mantle Cell Lymphoma✪ Dr. Zelenetz on Potential of Acalabrutinib and BGB-3111 in CLL✪ Dr. Wang on Acalabrutinib Activity in Mantle Cell Lymphoma✪ Common side-effects of BTK inhibitors (ibrutinib and acalabrutinib) in the treatment of CLLThe source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. Documents provided by Acerta Pharma BV: Study Protocol [PDF] May 23, 2016 Statistical Analysis Plan [PDF] January 30, 2018 More Information. You could also do it yourself at any point in time.It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology.

Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information.

Its investigational BTK inhibitor, ACP-196, also known as acalabrutinib, is currently in clinical development.

International biotechnology industry analysis, data and networking focused on translation, research, development, regulation, commercialization, partnering and funding.


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