You can help advance Endocr Dev. Various treatment options are available to someone with AIS, including reconstructive surgery and hormone therapy. The in-depth resources contain medical and scientific language that may be hard to understand. Review. Last updated: 11/18/2015 The unresponsiveness of the cell to the presence of androgenic hormones can impair or prevent the masculinization of male genitalia in the developing fetus, as well as impairing or preventing the development of male secondary sexual characteristics at puberty, but does not significantly impair femal… As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man.
Damage to nerves that sense feeling If you do not want your question posted, please let us know. People with this form of the condition have the external sex characteristics of females, but do not have a uterusand therefore do not menstruate and are unable to conceive a child (infertile). Clinical and molecular aspects of androgen insensitivity. Androgen Insensitivity Syndrome, or AIS, is a genetic condition, inherited (except for occasional spontaneous mutations), occurring in approximately 1 in 20,000 individuals. rare disease research! Get the latest public health information from CDC: Pediatr Endocrinol Rev. 1999 Mar 24 [updated 2017 May 11]. Hughes IA, Davies JD, Bunch TI, Pasterski V, Mastroyannopoulou K, MacDougall J. Androgen insensitivity syndrome. You may want to review these resources with a medical professional. Androgen insensitivity syndrome (AIS) is a rare condition that affects the development of a child's genitals and reproductive organs. Gottlieb B, Trifiro MA. Available from http://www.ncbi.nlm.nih.gov/books/NBK1429/ Hiort O.
2012 Oct 20;380(9851):1419-28. doi: 10.1016/S0140-6736(12)60071-3. Review. You can help advance We remove all identifying information when posting a question to protect your privacy. A health care provider may consider these conditions in the table below when making a diagnosis. COVID-19 is an emerging, rapidly evolving situation.As of October 1, 2020, the National Library of Medicine (NLM) will no longer offer Genetics Home Reference as a stand-alone website.
Lancet. Differential diagnoses include 17-beta-hydroxysteroid dehydrogenase deficiency, Leydig cell hypoplasia, XY complete gonadal dysgenesis (Swyer syndrome), 5-alpha-reductase type 2 deficiency and variants of congenital adrenal hyperplasia (see these terms). Inclusion on this list is not an endorsement by GARD.These resources provide more information about this condition or associated symptoms.
Seattle (WA): University of Washington, Seattle; 1993-2017. People with the same disease may not have They can direct you to research, resources, and services. uterus absent This table lists symptoms that people with this disease may have. Absent/underdeveloped fallopian tube Androgen insensitivity syndrome Androgen insensitivity syndrome (AIS) is when a person who is genetically male (who has one X and one Y chromosome) is resistant to male hormones (called androgens). Related diseases are conditions that have similar signs and symptoms. Children with androgen insensitivity syndrome (AIS) and their parents will be supported by a team of specialists who can offer ongoing information and care. Instead, much of the content from Genetics Home Reference has been transferred to MedlinePlus, the NLM’s flagship website for health information for patients, families, and the general public.The resources on this site should not be used as a substitute for professional medical care or advice. 2013;24:33-40. doi: 10.1159/000342499. rare disease research! Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. 2015 Jun;12(4):373-87. Review. Conditions with similar signs and symptoms from Orphanet Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. You can help advance Last updated: 9/1/2020