In addition, because restorative drugs aim to change brain structure and function, their effects are influenced by concomitant behavioral experience, a finding that informs selection of entry criteria, outcome measures, and biomarkers in a clinical trial setting. Recovery-based drugs have distinct therapeutic targets that are related to plasticity and growth after stroke, and in general, improvements in behavioral outcome are not accompanied by a reduction in infarct volume. Even in optimal settings, the dose of rehabilitation therapy may be lower than desired.Several key trials have described effects that readily meet the definition of clinically meaningful. Further evidence.A double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia.Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial.Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke [published online ahead of print April 18, 2015].Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury.Common drugs may influence motor recovery after stroke. Your doctor will weigh your personal odds of blood clots vs. bleeding.Both types of anti-clotting drugs raise your chances of bleeding. When introducing a drug to promote plasticity after neural injury, the best behavioral recovery requires rehabilitation to mold new connectionsSeveral techniques show promise to identify target populations. How to use an article measuring the effect of an intervention on surrogate end points. Public Health Service, Agency for Health Care Policy and ResearchVirtual reality in stroke rehabilitation: a meta-analysis and implications for clinicians.Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE): a randomized controlled trial protocol.Patient-reported measures provide unique insights into motor function after stroke.Meaningful change and responsiveness in common physical performance measures in older adults.White paper: “walking speed: the sixth vital sign.”Comprehensive overview of nursing and interdisciplinary rehabilitation care of the stroke patient: a scientific statement from the American Heart Association.Serotoninergic regulation of emotional and behavioural control processes.The neural and genetic basis of executive function: attention, cognitive flexibility, and response inhibition.The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression.Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy.Effects of antidepressants on functional recovery following stroke.Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke.Early fluoxetine treatment of post-stroke depression–a three-month double-blind placebo-controlled study with an open-label long-term follow up.Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial.Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial.Escitalopram and enhancement of cognitive recovery following stroke.Prevention of post-stroke generalized anxiety disorder, using escitalopram or problem-solving therapy.Inhibition of serotonin reuptake by antidepressants and cerebral microbleeds in the general population.Selective serotonin reuptake inhibitors and risk of cerebral bleeding.A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression?Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey.Suicide ideation among college students evidencing subclinical depression.Symptom profile of DSM-IV major and minor depressive disorders in first-ever stroke patients.Is improvement in impaired cognition and depressive symptoms in post-stroke patients associated with recovery in activities of daily living?

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