In studies, mepolizumab cut the necessity for hospitalisation due to asthma In December 2017, the FDA expanded mepolizumab's indication to treat adults with Common side effects in clinical trials included headache (19% of patients under mepolizumab treatment versus 18% under placebo), reactions at the site of injection (8% versus 3%), infections of the Single doses of 15 times the usual therapeutic dose have been tolerated in studies without significant side effects.No interaction studies have been conducted. NUCALA helps you gain asthma control and helps reduce your use of oral steroids like predisone. Nucala is indicated for the add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype [see Clinical Studies (14.1)].Limitations of UseNucala is not indicated for the relief of acute bronchospasm or status asthmaticus. Too many eosinophils may lead to inflammation in your lungs. **The mechanism of action of NUCALA is not fully understood.

The site you are linking to is not controlled or endorsed by GSK, and GSK is not responsible for the content provided on that site.Eosinophils [ee-uh-sin-uh-fils] are white blood cells that are a normal part of the body’s immune system. MECHANISM OF ACTION. The FDA approved it in November 2015.Mepolizumab has been investigated or is under investigation for the treatment of * NUCALA helps you gain asthma control and helps reduce your use of oral steroids like predisone.NUCALA is an add-on, prescription maintenance treatment for patients 6 and older with severe eosinophilic asthma. Inflammation can cause severe asthma attacks.In clinical studies, this helped identify patients whose asthma was more likely to respond to treatment with NUCALA.NUCALA is designed to reduce the number of eosinophils in your blood. NUCALA targets eosinophils, but what exactly does that mean?A simple blood test can measure the number of eosinophils in your blood. 12.1 Mechanism of Action 12.2 Pharmacodynamics 12.3 Pharmacokinetics 13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility 14 CLINICAL STUDIES 14.1 Severe Asthma 14.2 Eosinophilic Granulomatosis with Polyangiitis 16 HOW SUPPLIED/STORAGE AND HANDLING 17 PATIENT COUNSELING INFORMATION * The mechanism of action of NUCALA is not fully understood.Reducing the number of eosinophils in your blood may help reduce airway inflammation.See how NUCALA targets eosinophils to help reduce airway inflammation. Mepolizumab binds to IL-5 and therefore stops IL-5 from binding to its receptor on the surface of eosinophils. NUCALA should not be administered to patients with a history of hypersensitivity to mepolizumab or excipients in the formulation. Excipient information presented when available (limited, particularly for generics); consult specific product labeling.Solution Auto-injector, Subcutaneous [preservative free]: Nucala: 100 mg/mL (1 mL) [contains disodium edta, polysorbate 80]Solution Prefilled Syringe, Subcutaneous [preservative free]: Nucala: 100 mg/mL (1 mL) [contains disodium edta, polysorbate 80]Solution Reconstituted, Subcutaneous [preservative free]: Nucala: 100 mg (1 ea) [contains polysorbate 80] While eosinophils play a role in inflammation associated with asthma, the exact mechanism of mepolizumab is unknown. You are about to leave a GSK website. Mepolizumab is a fully humanized monoclonal antibody (IgG1 kappa) that targets human interleukin (IL)-5. NUCALA is not used to treat sudden breathing problems.If you don’t have prescription coverage and need help paying for your medicines, call us at Trademarks are owned by or licensed to the GSK group of companies. * The mechanism of action of NUCALA is not fully understood. Mepolizumab binds to IL-5 and prevents it from binding to its receptor, more specifically the interleukin 5 receptor alpha subunit, on the surface of eosinophil white blood cells. By clicking this link, you will be taken to a website that is independent from GSK. As with other monoclonal antibodies, the interaction potential is considered to be low.Mepolizumab binds to IL-5 and prevents it from binding to Phase III clinical trials in severe eosinophilic asthma were completed in 2014. Inflammation is a major component in the pathogenesis of asthma and eosinophilic granulomatosis with polyangiitis (EGPA), and many cell types and mediators are involved in inflammation. Reducing the number of eosinophils in your blood may help reduce airway inflammation.


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