CTRL + SPACE for auto-complete.Vertex Expanding into Diabetes Cell Therapy with Plans to Acquire Semma Initial preclinical work in animal models of diabetes has shown that transplantation of these cells by infusion into the liver is sufficient to control blood glucose levels. These data were presented in a plenary session at the International Society for Stem Cell Research (ISSCR) in June 2019. Semma was founded by Douglas Melton, Ph.D. and others to develop transformative therapies for patients who currently depend on insulin injections. Dr. Sanna will join Vertex as President of Semma. The companies anticipate the acquisition will close in the fourth quarter of 2019, subject to certain conditions, including the expiration of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act and other customary conditions. “If our studies are successful, it should be possible to apply our conclusions to human cells and provide a source of insulin-producing beta-cells for diabetics.”On June 29 at the International Society for Stem Cell Research (ISSCR) Annual Meeting 2019 in Los Angeles, Semma’s vp of cell biology research and development, Felicia Pagliuca, PhD, presented data from a pair of preclinical studies showing that Semma had achieved proof-of-concept for two lead programs for type 1 diabetes testing SC-islets in both non-human primates and pigs.In non-human primates, Semma said at the time, SC-islets were shown to successfully engraft and be highly functional, with the functional cells persisting over six weeks in the non-human primate liver. All Rights Reserved. Semma is working to bring this new therapeutic option to the clinic and improve the lives of patients with diabetes. BOSTON & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Sep. 3, 2019-- Vertex Pharmaceuticals Incorporated (NASDAQ: VRTX) today announced that the company has entered into a definitive agreement under which Vertex will acquire Semma Therapeutics, a privately held biotechnology company pioneering the use of stem cell-derived human islets as a potentially curative treatment for type 1 diabetes, for $950 million in cash. View the full release here: This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, including, without limitation, Dr. Leiden’s statements in the second paragraph of the press release, Dr. Altshuler’s statements in the third paragraph of the press release, Dr. Sanna’s statements in the fourth paragraph of the press release, Dr. Melton’s statements in the fifth paragraph of the press release, and statements regarding the timing of the potential closing of the transaction and the potential benefits of the acquisition. Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London, UK. Vertex Pharmaceuticals said today it has agreed to acquire Semma Therapeutics for $950 million cash, in a deal that would expand the buyer’s pipeline of specialty treatment with Semma’s potentially curative cell therapy for type 1 diabetes.Semma said its type 1 diabetes therapy is designed to incorporate a pair of advances: the ability to produce large quantities of functional human pancreatic beta cells that restore insulin secretion and ameliorate hypoglycemia in animal models and a novel device that encapsulates and protects these cells from the immune system, enabling durable implantation without the need for ongoing immunosuppressive therapy.“We see a substantial opportunity to transform the treatment paradigm for type 1 diabetes, a specialty disease cared for by endocrinologists, both by advancing the development and manufacturing of the cells themselves, as well as through the highly innovative cell/device combination,” Jeffrey Leiden, MD, PhD, Vertex’s chairman, president, and CEO, said in a statement. This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, including, without limitation, Dr. Leiden’s statements in the second paragraph of the press release, Dr. Altshuler’s statements in the third paragraph of the press release, Dr. Sanna’s statements in the fourth paragraph of the press release, Dr. Melton’s statements in the fifth paragraph of the press release, and statements regarding the timing of the potential closing of the transaction and the potential benefits of the acquisition. We use cookies on this website. Under the terms of the acquisition, Vertex will acquire all outstanding shares of Semma, and Semma will become a separate operating subsidiary of Vertex. Subscriber Sign In Semma Therapeutics might count Medtronic and Novartis among its venture investors, but it is Vertex Pharmaceuticals that has managed to acquire it. Under the terms of the acquisition, Vertex will acquire all outstanding shares of Semma for The SC-islets have been transplanted in both small and large animal models of diabetes where they have been shown to survive for more than half a year, the company added.Semma’s work is intended to advance breakthrough stem cell differentiation technology developed in the laboratory of Douglas A. Melton at Harvard University in 2014 and licensed exclusively to Semma toward generation of cell therapies. Implantation of the islet cell-filled device has the potential to replace the missing beta cells in a diabetic patient without requiring patient immunosuppression. Recent work in the laboratory of Professor Douglas Melton led to the discovery of a method to generate billions of functional, insulin-producing beta cells in the laboratory. Under the terms of the deal, Vertex will acquire all outstanding Semma shares for $950 million in cash. Vertex Pharmaceuticals announced a deal to buy Semma Therapeutics. By continuing to use our site, you are agreeing to the use of cookies as set in our

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