It is usually given by a doctor or nurse in a doctor's office or healthcare facility. The central and peripheral volume of distribution (Vd) of benralizumab was 3.2 L and 2.5 L, respectively, for a 70-kg individual. For the full list of excipients, see section 6.1. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not change your dose or dosing schedule without your doctor's advice. PB - F.A. Talk to your doctor about how to treat symptoms of a sudden asthma attack. It works by reducing a certain type of white blood cell to help decrease swelling and irritation of the airways to allow for easier breathing. Call your doctor if you have any unusual problems while receiving this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (In case of overdose, call the poison control helpline at 1-800-222-1222. BT - Davis's Drug Guide FASENRA (benralizumab) Injection, for Subcutaneous Use. AU - Vallerand,April Hazard, Benralizumab is a humanized monoclonal antibody to the interleukin-5 (IL-5) receptor alpha which leads to a decrease in production and maturation of eosinophils and is used therapeutically to reduce allergic symptoms in patients with eosinophilic asthma. Benralizumab is for people whose asthma is not well controlled with other medications.Benralizumab may also be used for purposes not listed in this medication guide.Before you receive benralizumab, tell your doctor about all your medical conditions or You should not be treated with benralizumab if you are allergic to it.a parasite infection (such as roundworms or tapeworms); orFollow your doctor's instructions about receiving benralizumab It may not be safe to breast-feed a baby while you are using this medicine. How should this medicine be used? Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … UR - https://www.unboundmedicine.com/washingtonmanual/view/Davis-Drug-Guide/110555/all/benralizumab Benralizumab is administered by subcutaneous injection. You may report side effects to the FDA at 1-800-332-1088.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. USP drug classification [BR:br08302] Respiratory Tract/Pulmonary Agents Respiratory Tract Agents, Other Immunomodulators Benralizumab D09874 Benralizumab (USAN/INN) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 22 Respiratory organ agents 229 Miscellaneous 2290 Miscellaneous D09874 Benralizumab (USAN/INN); Benralizumab (genetical … Benralizumab (INN, trade name Fasenra) is a monoclonal antibody which developed by MedImmune for the treatment of asthma.It is directed against the alpha-chain of the interleukin-5 receptor ().. Two Phase 3 clinical trials of benralizumab, SIROCCO and CALIMA, reported meeting their primary endpoints in 2016. Information is also available online at Ask your pharmacist any questions you have about benralizumab injection.It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Benralizumab is a monoclonal antibody that affects the actions of the body's immune system. Individual plans may vary and formulary information changes. ET - 16

Drug substance (active ingredient) _____11 _____15 . A healthcare provider will give you this injection, usually once every 4 weeks at first and then once every 8 weeks.Follow your doctor's dosing instructions very carefully.If you've been using a steroid medication, do not stop using it unless your doctor tells you to.You may need frequent medical tests to help your doctor determine how long to treat you with benralizumab.Asthma is often treated with a combination of drugs. Do not use to treat sudden breathing problems. These are not all of the side effects that may occur. Ask your doctor about any risks.Benralizumab should not be given to a child younger than 12 years old.Before you start treatment with benralizumab, your doctor may perform tests to measure your eosinophil levels.Benralizumab is injected under the skin. Benralizumab is a humanized IgG1 monoclonal antibody that is degraded by proteolytic enzymes widely distributed in the body and not restricted to hepatic tissue.

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