You can also search for this author in SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells.

Precursor mass tolerance was set to 10 ppm and fragment mass tolerance was set to 0.05 Da.

Proteomics 15, 374–382, 10.1002/pmic.201400379 (2015).Johnson, H., Lescarbeau, R. S., Gutierrez, J.

You can also search for this author in The cells were analyzed on the BD FACSVerseLeemans, C. R., Braakhuis, B. J. eCollection 2020 Mar 24.Lechner C, Flaßhoff M, Falke H, Preu L, Loaëc N, Meijer L, Knapp S, Chaikuad A, Kunick C.Molecules. AC was supported by Department of Science and Technology (DST) grants (SERC/LS-439/2011 and SR/SO/HS/0208/2013). Western blot analysis was carried out as described previouslyApoptosis was determined by staining cells with annexin Vfluorescein isothiocyanate (FITC) and PI labeling as per manufacturer’s instructions (Becton Dickinson, Franklin Lakes, NJ). Mass spectrometry data was searched against NCBI Human RefSeq protein database (Version 65) supplemented with common contaminants using Mascot (version 2.2.0) and SEQUEST search algorithms. This site needs JavaScript to work properly. Mechanism of dual specificity kinase activity of DYRK1A. Please enable it to take advantage of the complete set of features! doi: 10.1016/j.pharmthera.2015.03.004. Cell 96, 857–868, S0092-8674(00)80595-4 [pii] (1999).Zheng, W. H., Kar, S. & Quirion, R. Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. provided cell lines and scientific inputs. & White, F. M. Phosphotyrosine profiling of NSCLC cells in response to EGF and HGF reveals network specific mediators of invasion. 2020 Mar 11;5(11):5620-5628. doi: 10.1021/acsomega.9b02375. Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)- and ErbB family-targeted agents in the treatment of head and neck squamous cell carcinoma (HNSCC).
Although most extensively characterised for its role in brain development, DYRK1A is over-expressed in a variety of diseases including a number of human malignancies, such as haematological and brain cancers.

We thank Ms. Neha Deshpande for technical inputs with fluorescence imaging.Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, IndiaAneesha Radhakrishnan, Vishalakshi Nanjappa, Remya Raja, Gajanan Sathe, Vinuth N. Puttamallesh, Ankit P. Jain, Sneha M. Pinto, Sandip Chavan, Nandini A. Sahasrabuddhe, T. S. Keshava Prasad, Geethanjali Sukumar, Harsha Gowda & Aditi ChatterjeeDepartment of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, 605014, IndiaAmrita School of Biotechnology, Amrita University, Kollam, 690 525, IndiaVishalakshi Nanjappa, Vinuth N. Puttamallesh & T. S. Keshava PrasadManipal University, Madhav Nagar, 576104, Manipal, IndiaSchool of Biotechnology, KIIT University, Bhubaneswar, 751024, IndiaDepartment of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, IndiaDepartment of Neuro-Virology, National Institute of Mental Health and Neurosciences, Bangalore, 560029, IndiaYU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, India, 575018T. DYRK1A primary function occurs during early development, where this protein regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells. Nat Biotechnol 26, 164–167, 10.1038/nbt0208-164 (2008).Chatterjee, A., Mambo, E., Zhang, Y., Deweese, T. & Sidransky, D. Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress. We checked the expression of DYRK1A in primary HNSCC tissues. All cell lines were grown in a humidified incubator with 5% COEach cell line was grown to 70% confluence and then maintained in serum free medium for 12 h before the cells were harvested for protein isolation.

RR is a recipient of research associateship from DBT.

Nat Cell Biol 10, 138–148, 10.1038/ncb1676 (2008).Brunet, A. et al. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. P.P.M., T.S.K.P., G.Suk, A.Ran, A.P., H.G. Name must be less than 100 characters TMAs obtained commercially were processed and immunohistochemical staining was carried out as described previouslyCells were cultured to 70% confluency and the proteins were harvested in RIPA lysis buffer (10 mM Tris pH 7.4, 150 mM NaCl, 5 mM EDTA, 1% Triton-X-100, 0.1% SDS containing protease and phosphatase inhibitor cocktails) and sonicated. The relevance of DYRK1A in a … CAL 27 cells were cultured in DMEM medium supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin. N Engl J Med 344, 1038–1042, MJBA-441402 (2001).Druker, B. J. et al. Human Proteinpedia enables sharing of human protein data. To view a copy of this license, visit 2019 Dec 27;294(52):20164-20176. doi: 10.1074/jbc.RA119.010809. Epub 2010 Dec 3.Thomas MSC, Ojinaga Alfageme O, D'Souza H, Patkee PA, Rutherford MA, Mok KY, Hardy J, Karmiloff-Smith A; LonDownS Consortium.Res Dev Disabil.

We investigated the Inhibition of DYRK1A reduces the invasive ability of the HNSCC cells.Having observed DYRK1A affects both HNSCC cellular proliferation and invasive potential Next we studied the role of inhibition DYRK1A in apoptosis in HNSCC cells.

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